In the 16th and 17th centuries, European settlers in the present-day department of Caaguazú were threatened by the Portuguese Bandeirant and Guaicurú Indians, preventing permanent settlement of the land for many years.
Soto has played club football in Paraguay, Spain, and Argentina for Guaraní, Elche, Huracán, Libertad, 12 de Octubre, Coquimbo Unido, 9 de Julio, Crucero del Norte and Deportivo Caaguazú.
The city is located near the Ybyturuzú, part of the Caaguazú mountain chain.
Caaguazú is the home department of several Paraguayan personalities, such as the writer Mario Halley Mora and the musician Cayo Sila Godoy.
Juan Eulogio Estigarribia, a populated place in Caaguazú Department, Paraguay
Santa Rosa del Mbutuy is a town and distrito in the Caaguazú department of Paraguay that is best described as the 'Cruce del Mbutuy' by residents of the Santa Rosa District, where it is located, because of the intersection of two major roads that the town is built around.